KMID : 0892920160250060342
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Experimental Neurobiology 2016 Volume.25 No. 6 p.342 ~ p.346
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Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERB¥á Knock-out Mice
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Lee Jae-Hyun
Ko Hyoung-Gon Kim Kyung-Jin Kaang Bong-Kiun
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Abstract
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Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERB¥á knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERB¥á in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERB¥á induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
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KEYWORD
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Circadian rhythm, REV-ERB¥á, Nociception, Inflammatory pain
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